癌症-免疫动态的表观遗传编排:机制,技术和临床进展
Yuanjun Lu1, Shuoshuo Ma2, Yau-Tuen Chan3
1Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China; School of Chinese Medicine, the University of Hong Kong, Hong Kong Special Administrative Region of China.
Journal of advanced research
|September 12, 2025
概括
表观遗传变化通过破坏癌症免疫循环来驱动癌症免疫逃避. 针对这些表观遗传改变提供了一个有希望的策略,以增强抗瘤免疫力和克服治疗耐药性.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 表观遗传失调是癌症免疫规避的核心.
- 它使瘤抗原沉默,损害免疫细胞,并创建一个免疫抑制瘤微环境.
- 这些干扰阻碍了癌症免疫循环,促进了瘤的进展.
研究的目的:
- 系统地审查表观遗传变化如何损害整个癌症免疫周期的抗瘤免疫力.
- 整合机理学证据,突出表观遗传调节器和免疫细胞之间的交叉声.
- 强调用于发现治疗点和分层患者的新兴技术.
主要方法:
- 对现有文献进行系统审查.
- 整合了关于癌症免疫中的表观遗传调节的机制研究.
- 突出了单细胞表观基因组学,空间多基因组学和CRISPR屏幕方面的进展.
主要成果:
- 表观遗传改变会破坏癌症免疫周期的多个阶段,包括抗原呈现和T细胞功能.
- 表观遗传调节器和免疫细胞之间的交叉声会显著影响抗瘤反应.
- 新兴技术正在揭示新的治疗点,并改善患者分层.
结论:
- 表观遗传干预,单独或与免疫疗法结合,可以重振抗瘤免疫力.
- 绘制免疫表观遗传景观可以实现精确的免疫疗法策略.
- 表观遗传重编程对于克服癌症免疫规避至关重要.
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