γδ T 细胞:在结直肠癌发生过程中调节炎症癌症转变的双重功能
Ruihan Guo1, Yimin Chen1, Peizhe Lin2
1College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Critical reviews in oncology/hematology
|September 12, 2025
概括
玛-三角形T细胞在慢性肠道炎症和结直肠癌 (CRC) 中起着双重作用. 了解它们复杂的功能为针对CRC的向免疫疗法提供了新的途径.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 慢性肠道炎症是结肠直肠癌 (CRC) 的一个主要风险因素.
- 玛-三角形 (γδ) T 细胞是炎症性肠病 (IBD) 和CRC发展的关键调节者.
- γδ T 细胞表现出双重作用,调解抗炎和促炎反应.
研究的目的:
- 阐明 γδ T 细胞在从慢性肠道炎症过渡到结直肠癌中的双重作用.
- 探索CRC发展背后的免疫病理机制.
- 审查基于γδT细胞的CRC免疫疗法的临床前和临床进展.
主要方法:
- 对IBD和CRC中γδT细胞功能的临床前和临床数据的审查.
- 对细胞因子 (IL-17,IL-22,IFN-γ) 和信号通路 (STAT3) 的分析.
- 评估涉及γδ T细胞的免疫治疗策略.
主要成果:
- γδ T 细胞分泌IL-22用于粘膜愈合,但IL-17促进炎症和CRC.
- 某些γδ T 细胞子集通过细胞毒性和IFN-γ生产来增强抗瘤免疫力.
- 其他子集通过免疫抑制和血管生成促进CRC,由IL-17和IL-22.2驱动.
- IL-17/IL-22-STAT3通路将慢性炎症与瘤转化联系在一起.
结论:
- 彻底了解 γδ T 细胞双重性对于破译 CRC 免疫病理学至关重要.
- 向γδT细胞为新型CRC免疫疗法提供了一个有希望的理论基础.
- 早期的临床试验表明,gδ T 细胞调节在减少炎症和改善CRC治疗结果方面具有潜力.
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