治疗结果对Mycobacterium abscessus复杂肺病死亡率的影响
Kyung-Wook Jo1, Jung Bok Lee2, Jiwon Lee3
1Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Chest
|September 12, 2025
概括
培养转换是患有 Mycobacterium abscessus复杂肺病 (MABC-PD) 的患者生存的关键指标. 实现培养转换显著降低了死亡风险,突出了改善治疗策略的必要性.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
背景情况:
- 菌根杆菌综合体 (MABC) 导致难以治疗的肺部疾病 (PD).
- 在MABC-PD中培养转换的预后意义仍未得到充分研究.
- 本研究涉及培养物转换对MABC-PD患者死亡率的影响.
研究的目的:
- 研究MABC-PD患者的培养转换和全因死亡率之间的关联.
- 确定实现培养转换是否是生存的重要预后因素.
主要方法:
- 对172名MABC-PD患者进行了回顾性分析,这些患者接受了基于类的治疗.
- 在治疗结束时评估的培养转换.
- 扩展的Cox比例危险模型用于分析死亡风险,以培养物转换为时间依赖的共变量.
主要成果:
- 58.1%的患者实现了培养转换;41.9%没有.
- 在没有培养转换的患者中,死亡率明显高 (22.5%对6.0%,P = .002).
- 没有培养转换的患者面临1.57倍的死亡风险 (95% CI,1.13-2.20;P = .008).
结论:
- 治疗结束时的培养转换是MABC-PD的关键预后因素.
- 无法实现培养转换与死亡率的增加密切相关.
- 新型治疗策略对于改善MABC-PD的培养转化率和长期结果至关重要.
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