剖析焦虑和认知功能之间的共同遗传架构.
Ming Yang1, Zhini Yu1, Zhengqi Wei1
1Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guangxi Key Laboratory of Diabetic Systems Medicine, School of Public Health, Guilin Medical University, Guilin, Guangxi, 541199, China.
Journal of affective disorders
|September 12, 2025
概括
这项研究揭示了焦虑和认知衰退之间的共同遗传基础,表明焦虑通过共同的遗传因素对认知功能产生负面影响. 对这些遗传联系的进一步研究可以为未来的并发症研究提供信息.
科学领域:
- 神经遗传学 神经遗传学
- 精神病学遗传学 精神病学遗传学
- 认知神经科学 认知神经科学
背景情况:
- 越来越多的证据将焦虑与增加认知能力下降风险联系在一起.
- 这种关联的潜在遗传机制在很大程度上是未知的.
- 这项研究研究了共同的遗传结构和焦虑与认知功能之间的因果关系.
研究的目的:
- 探索焦虑和认知功能之间的遗传相关性.
- 用双向门德尔随机化研究焦虑和认知功能之间的因果关系.
- 确定共同的基因位置和功能基因,涉及到焦虑和认知功能.
主要方法:
- 全基因组关联研究 (GWAS) 的数据使用链接不平衡得分回归 (LDSC) 和高定义概率 (HDL) 来分析遗传相关性.
- 使用双向门德尔随机化 (MR) 来评估因果关系.
- 交叉特征元分析,分层LDSC和基于总结的MR (SMR) 用于识别共享的位置和功能基因.
主要成果:
- 在焦虑和认知功能之间发现了显著的负遗传相关性.
- 核磁共振分析支持焦虑对认知功能的有害影响 (β = -0.121,P = 7.59 × 10-3).
- 确定了四种新的共享单核酸多态 (SNP),其中ITIH4基因始终涉及. 丰富分析突出显示了大脑区域 (例如,额叶皮层) 和细胞类型 (例如,GABAergic神经元,星体细胞).
结论:
- 一个共同的遗传基础是焦虑和认知功能的基础,由遗传相关性和共享基因证明.
- 这些发现为焦虑和认知衰退的共患性提供了新的见解.
- 已确定的遗传因素和生物途径为未来研究它们的相互联系提供了途径.
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