在严重的额头肌反和休克中使用的功能结果 (FOCUS-MR):单中心注册表
Mustafa Suppah1, Sant Kumar1, Pallavi Bellamkonda1
1Cardiology Department at St. Joseph's Hospital and Medical Center, Phoenix, United States of America; Cardiology Department at Creighton University, Phoenix, United States of America.
概括
通过MitraClip进行透气管边缘到边缘的 mitra 修复 (TEER) 在患有心脏病或混合休克的患者中可用于严重的 mitra 吐 (MR). 这种干预方法取得了很高的程序性成功,并减少了MR的严重程度,尽管需要进一步的前性研究.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 心脏门疾病 心脏门疾病
背景情况:
- 严重的额叶吐 (MR) 带来了显著的死亡风险,特别是在发生震惊的患者中.
- 手术修复是急性初级MR的标准,但对于重症患者来说往往是不可行的.
- 使用MitraClip进行跨导管边缘至边缘膜修复 (TEER) 为高风险患者提供了一个有前途的替代方案.
研究的目的:
- 评估MitraClip植入在患有严重MR和心脏或混合休克的患者中的可行性,安全性和临床结果.
- 为了比较心脏性休克患者与接受TEER的混合休克患者之间的结果.
主要方法:
- 对47名患有严重MR和心脏病 (n=32) 或混合休克 (n=15) 的患者进行了回顾性队列研究,这些患者接受了MitraClip治疗.
- 对程序成功的评估,定义为成功部署剪贴和将MR减少到≤2.
- 冲击亚型之间的基线特征,血液动力学参数和短期和长期结果的比较.
主要成果:
- 实现了100%的程序成功,显著减少了MR的严重程度,从4级降至≤2级 (p < 0.001).
- 住院死亡率为8.5%,一年死亡率为25.5%.
- 混合休克患者的住院死亡率较高 (20%对3.1%),但一年内再入院率较低 (21.4%对58.6%).
结论:
- 植入MitraClip是一种可行的和有效的治疗严重的MR在心脏或混合休克的患者.
- 该程序带来了高的成功率和显著的MR减少.
- 需要进一步的前性研究来验证这些发现并优化患者选择标准.
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