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通过CDK4/6-RB信号和化学遗传学进行人类DNA复制许可的时间控制

Anastasia Sosenko Piscitello1, Ann-Sofie Nilsson2, Michael Hawgood2

  • 1Department of Molecular and Cellular Biology, University of Geneva, Geneva, Switzerland.

Nature communications
|September 12, 2025
PubMed
概括

循环素依赖性激酶4/6 (CDK4/6) 通过抵消RB蛋白质,促进人类细胞中的DNA复制原产地许可. CDK4/6抑制剂阻断了这一过程,影响了细胞增殖和癌症治疗.

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