相关实验视频
Updated: Jan 18, 2026

10:59
New Methods to Study Gustatory Coding
Published on: June 29, 2017
9.9K
味道和鼻后气味唤起了人类岛内共享的风味特异的神经代码
Putu Agus Khorisantono1, Maria G Veldhuizen2,3,4,5, Janina Seubert6
1Division of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, SE-171 77, Stockholm, Sweden. putu.agus.khorisantono@ki.se.
Nature communications
|September 12, 2025
概括
鼻后气味激活大脑的味觉区域,显示与实际味道重叠的神经模式. 这项研究阐明了大脑如何整合气味和味道来创造味道感知.
科学领域:
- 神经科学是一个神经科学.
- 感官科学 感官科学
- 食品科学 食品科学 食品科学
背景情况:
- 味觉感知源于味觉和鼻后嗅觉信号的整合.
- 人类大脑中这种跨模式集成的基础的神经机制,特别是岛屿中,尚未完全理解.
研究的目的:
- 为了调查反鼻鼻臭剂是否会引起类似的神经编码模式的岛屿作为他们的配对品味剂.
- 探索味觉和嗅觉感官信息在味觉感知过程中的皮质整合.
主要方法:
- 在健康的参与者身上利用了一种口味结合范式.
- 使用功能磁共振成像 (fMRI) 来捕捉大脑活动.
- 应用多变量模式分析 (MVPA) 来分析味道和气味的神经表征.
主要成果:
- 多变量模式分析成功地将岛内的鼻后气味分类.
- 在后鼻气味和与之相关的味道之间发现了重叠的神经表征,特别是在腹腔前部岛屿中.
- 观察到岛内味觉表现的时间偏移,与动物味觉皮层的发现相一致.
结论:
- 鼻后嗅觉刺激在胰岛中唤起神经模式,与味觉刺激的神经模式重叠,支持一种统一的味道神经基础.
- 这些发现凸显了口味和鼻后嗅觉处理在构建味觉感知中的显著交叉模式相互作用.
相关概念视频
Olfaction
48.2K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
48.2K
Gustation
51.9K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
51.9K
The Physiology of Taste
7.2K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
7.2K
Taste Buds and Receptors
4.6K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
4.6K
Physiology of Smell and Olfactory Pathway
12.4K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
12.4K
Olfactory Receptors: Location and Structure
11.2K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
11.2K

