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Hallucinogens and Psychedelics

Hallucinogens and Psychedelics

Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...

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Dissecting the Non-human Primate Brain in Stereotaxic Space

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非人类灵长类动物的迷幻研究:过去和未来

Jamie C Masthay¹, Alex C Kwan^2,3,4, Steve W C Chang^5,6,7,8

¹Department of Psychology, Yale University, New Haven, CT, USA.

Molecular psychiatry

|September 12, 2025

概括

接触经典迷幻药物的非人类灵长类动物 (NHPs) 显示出与人类相似的行为变化和耐受性. 这些NHP模型提供了关于迷幻药对大脑的影响和潜在的精神病学应用的见解.

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科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
灵长类动物学灵长类动物学

背景情况:

在非人类灵长类动物 (NHPs) 中研究了血清或"经典"迷幻药物.
国民健康计划研究提供了对药物对大脑和人类相关物种行为的影响的见解.
在NHP迷幻研究中的变化可能源于药物类型,剂量和个体差异.

研究的目的:

审查从NHP中迷幻研究中获得的知识.
突出NHP作为精神疾病临床前模型的潜力.
建议NHP迷幻模型的未来研究方向.

主要方法:

对多种NHP物种中迷幻化合物的现有文献的审查.
在NHP研究中报告的行为和药物效应的分析.
将NHP的发现与人类和动物的迷幻研究进行比较.

主要成果:

迷幻药在NHP中诱导自发和操作行为的特征变化.
在NHP中观察到的效应包括耐受性发展和低滥用责任,反映了人类的反应.
关于NHPs视觉幻觉的证据仍然没有确定性.
国家心理健康计划研究支持并连接了人类和动物迷幻药物研究的发现.

结论:

非人类灵长类动物作为有价值的临床前模型来理解迷幻效应.
国家心理健康计划的研究有助于阐明迷幻的作用机制.
需要进一步的研究来完善精神病应用的NHP模型,并确保准确性.