燃烧多发性骨髓瘤感染风险增加:从选的iStopMM研究中得出的结果
Lærke Sloth Andersen1, Ricardo Berenguer Navarro2, Sara Ekberg2
1Department of Hematology, Rigshospitalet, Copenhagen, Denmark.
Leukemia
|September 12, 2025
概括
与未确定的意义上的单克隆性骨髓瘤病变 (MGUS) 或没有骨髓瘤前体相比,患有燃烧性多发性骨髓瘤 (SMM) 的人面临的感染风险明显更高. 这凸显了SMM中未被认可的感染负担.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 多发性骨髓瘤 (MM) 是致病率和死亡率的重要原因,在前体条件下感染风险较高.
- 已知未确定意义的单克隆性淋巴瘤病变 (MGUS) 会增加感染风险,但对化多发性髓瘤 (SMM) 的数据有限.
研究的目的:
- 调查和量化被诊断患有燃烧多发性髓瘤 (SMM) 的个体的感染风险.
- 将SMM患者的感染率与MGUS患者和没有MM前体的个体进行比较.
主要方法:
- 利用了来自iStopMM研究的数据,选了75422名40岁以上的冰岛人.
- 根据年龄和性别,将SMM患者 (n=188) 与MGUS患者 (n=188) 和MGUS免费比较者 (n=810) 相匹配.
- 分析了使用全国性注册表 (ICD-10代码,抗菌药物处方) 和Cox比例危险模型的感染结果,并调整了免疫衰竭.
主要成果:
- 与比较者相比,SMM患者的感染率 (HR 1.36) 和抗菌药物处方 (HR 1.24) 显著增加.
- 与MGUS患者相比,SMM患者的感染风险也增加了 (HR 1.37).
- 针对免疫衰竭的调整部分减轻了这些关联,表明其在调节感染风险方面的作用.
结论:
- 这项研究表明,与MGUS和没有MM前体的个人相比,SMM患者的感染风险显著增加.
- 这些发现表明,在日益增长的多发性骨髓瘤群体中,感染负担未被充分认识到.
- 这些结果强调了监测和管理SMM患者感染风险的重要性.
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