N,N-二甲基三胺对连接组波,主观体验和比较迷幻体验的影响
Jakub Vohryzek1,2, Andrea I Luppi3,4,5,6, Selen Atasoy3,7
1Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, United Kingdom. jakub.vohryzek@upf.edu.
概括
像N,N-二甲基三胺 (DMT) 这样的迷幻化合物会改变整个结构连接组的脑功能. 在DMT下大脑活动的变化与主观经验相关,为意识提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 计算神经科学是一种神经科学.
背景情况:
- 了解大脑的结构功能关系是神经科学的关键.
- 迷幻药提供了独特的模型来研究神经递质对感知,认知和意识的影响.
- 迷幻药引起的大脑功能变化在结构连接组中传播.
研究的目的:
- 在人类连接组的背景下,研究N,N-二甲基三胺 (DMT) 对大脑功能的影响.
- 应用连接组的和分解来分析迷幻诱导的大脑活动的变化.
- 探索大脑功能变化与主观体验强度之间的关系.
主要方法:
- 利用连接体和分解,这是一个分析大脑功能依赖网络结构的框架.
- 向参与者服用N,N-二甲基三胺 (DMT).
- 测量了连接组和曲谱的变化和随时间变化的曲谱.
主要成果:
- 在DMT下,连接组的和曲目被显著重塑,类似于其他迷幻药物 (psilocybin,LSD,ketamine).
- 在DMT下,连接组波的曲谱变增加,反映了其他迷幻药的效果.
- 测量了与实时主观体验强度相关联的连接组波的能量频谱差异和曲目.
结论:
- 像其他迷幻药一样,DMT会以一种依赖于结构连接组的方式改变大脑功能.
- 连接组波中增加的剧目和能量频谱差异反映了迷幻状态.
- 连接组的和分析提供了主观经验的时间解析指数,突出了大脑网络动态和意识之间的直接联系.
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