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相关概念视频

Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

16.7K
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
16.7K
Development of the Heart01:27

Development of the Heart

2.1K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
2.1K
Cellular Differentiation00:57

Cellular Differentiation

5.1K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
5.1K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

1.4K
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
1.4K
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

8.8K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
8.8K
Specialized Characteristics of Cardiac Muscles01:27

Specialized Characteristics of Cardiac Muscles

4.0K
The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy...
4.0K

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Technologies and applications of current human cardiac organoids.

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相关实验视频

Updated: Jan 18, 2026

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts
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Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts

Published on: March 22, 2017

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心脏发育,细胞组成和功能:从调节机制到应用

Huan-Yu Zhao1, Jie-Bing Jiang1, Shu-Na Wang1

  • 1Department of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.

Cells
|September 13, 2025
PubMed
概括

这篇评论探讨了心脏发育和细胞功能,将心脏发生与精密医学联系起来. 它强调了心血管疾病再生疗法的突破.

科学领域:

  • 心血管医学 心血管医学
  • 发展生物学 发展生物学
  • 再生医学是一种再生医学.

背景情况:

  • 了解心脏发生和心脏细胞功能对于心血管医学和精密医学至关重要.
  • 心脏从胚胎到成熟的发展涉及复杂的信号通路和转录网络.

研究的目的:

  • 综合审查从胚胎发育到成熟的心脏组成和功能.
  • 突出与心脏发育和细胞功能相关的治疗策略的突破.
  • 总结基因/细胞疗法,有机体发育和心血管疾病再生医学方面的进展.

主要方法:

  • 检查空间时间特定的信号通路驱动心脏器官生成.
  • 分析前代细胞命运决定中的转录网络.
  • 系统地呈现成熟心脏细胞类型的分子生物标志物和功能特征.

主要成果:

  • 详细阐述了心脏发育的分子机制.
  • 系统地呈现成熟心脏细胞类型的特征.
  • 关于再生医学应用的最新进展的摘要.

结论:

  • 为精确的心血管干预提供了理论基础.
关键词:
这是心脏器官的有机体.心脏发生的过程 (cardiogenesis)细胞治疗疗法细胞治疗疗法基因治疗的基因疗法心肌细胞的功能的功能.再生医学是一种再生医学.组织工程是组织工程.

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Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

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Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
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Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

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相关实验视频

Last Updated: Jan 18, 2026

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts
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Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts

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Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
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Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Published on: March 1, 2016

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Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
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Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

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  • 整合了心脏发生,细胞架构和再生医学的治疗翻译.
  • 强调基因/细胞疗法,有机体开发和组织工程方面的突破.