固体瘤和肉瘤中的癌症相关纤维细胞:异质性,功能和治疗影响
Omar Badran1,2, Idan Cohen2, Gil Bar-Sela1,2
1Department of Oncology, Emek Medical Center, Afula 1834111, Israel.
Cells
|September 13, 2025
概括
癌症相关纤维细胞 (CAF) 是多样化的细胞,驱动瘤生长和抵抗. 了解CAF亚型,特别是在肉瘤中,是开发新癌症疗法的关键.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 瘤微环境研究 研究
背景情况:
- 与癌症相关的纤维细胞 (CAF) 在瘤微环境 (TME) 中显著影响瘤进展,免疫逃避和治疗耐药性.
- 单细胞转录组学揭示了至少五种不同的CAF亚型 (myCAFs,iCAFs,apCAFs,meCAFs,vCAFs/dCAFs) 具有独特的特征.
- 在上皮癌中,CAF的作用已经得到了很好的证实,但它们在来自介质细胞的瘤中的功能仍然不太清楚,这在区分恶性细胞和脑膜细胞方面构成了挑战.
研究的目的:
- 在各种固体瘤中审查CAF的异质性和可塑性.
- 专注于CAF和CAF类细胞在肉瘤中的特定作用,包括免疫逃避,上皮细胞转化为介质细胞 (EMT) 和治疗耐药性.
- 探索针对CAF或重新编程CAF及其作为生物标志物的潜力的新策略.
主要方法:
- 这是一篇叙事性综述,综合了CAF现有研究.
- 分析单细胞转录组学数据以识别CAF亚型及其功能.
- 检查有关瘤中CAF类细胞及其对瘤行为的影响的新兴证据.
主要成果:
- CAF表现出显著的异质性和可塑性,有助于免疫抑制,EMT和对各种癌症疗法的耐药性.
- 瘤中的CAF类细胞与瘤入侵,免疫排除和转移性的形成有关.
- 在CAF分析中,CAF被认为是患者分层和个性化治疗方法的生物标志物.
结论:
- 了解CAFs的多样化生物学,特别是在具有挑战性的瘤类型 (如瘤) 中,对于推进癌症治疗至关重要.
- 向或重编程CAF是一种有希望的途径,可以克服治疗耐药性并改善患者的治疗结果.
- 对不同癌症的CAF异质性和功能的进一步研究将有助于开发更有效,个性化的癌症疗法.
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