早期癌症全球趋势的当代变化:发病率和死亡率 (2000-2021)
Pojsakorn Danpanichkul1, Yanfang Pang2,3,4, Supapitch Sirimangklanurak5
1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Cancers
|September 13, 2025
概括
全球早期发病癌症 (15-49岁) 的负担正在上升,从2000年至2021年期间的发病率正在增加. 需要立即采取全球行动,以应对这一日益严重的公共卫生挑战.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 全球健康 全球健康
背景情况:
- 全球早期癌症发病率 (15-49岁) 显著增加.
- 早期发病的癌症在全球范围内带来了重大的社会和经济挑战.
- 需要对早期癌症发病率和死亡率进行最新的全球估计.
研究的目的:
- 为早期癌症的发病率和死亡率提供最新的全球估计.
- 分析2000年至2021年早期癌症发病率和死亡率的趋势.
- 为了确定不同地区和不同癌症类型的早期癌症负担的变化.
主要方法:
- 全球疾病负担分析研究2021年数据.
- 描述发病率,死亡率,年龄标准化发病率 (ASIR) 和年龄标准化死亡率 (ASDR) 的早期发病癌症 (15-49岁).
- 加入点回归分析用于评估2000年至2021年的变化,计算年度百分比变化 (APC).
主要成果:
- 在2021年,全球记录了316万例新发病例和989650例早期癌症死亡.
- 从2000年到2021年,全球早期癌症的ASIR每年增加0.40%,女性 (0.62%) 的增加高于男性 (0.14%).
- 乳腺癌,非黑色素瘤皮肤癌和宫癌的发病率负担最高,而非黑色素瘤皮肤癌,甲状腺癌和丸癌的ASIR增加率最高. 周围神经系统癌症和多发性骨髓瘤显示最大的ASDR增加.
结论:
- 在2000年至2021年间,早期癌症的年龄调整发病率在全球范围内有所上升.
- 在全球不同地区和特定癌症类型中,发生率趋势存在显著差异.
- 迫切的全球,区域和国家干预措施是必要的,以减轻早期癌症日益增加的负担.
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