在急性白血病患者中确定与心血管并发症相关的危险因素:系统性审查
Arezoo Abasi1, Haleh Ayatollahi2, Soroush Rad3
1Student Research Committee, Iran University of Medical Sciences, Tehran 14496-14535, Iran.
Cancers
|September 13, 2025
概括
由于疾病和治疗因素,急性白血病 (AL) 患者经常出现心血管并发症. 识别人口统计,并发症和遗传等风险因素有助于早期检测和更好的结果.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 急性白血病 (AL) 患者因疾病和治疗而面临心血管风险增加.
- 并发症包括心力衰竭,心律失常,心肌梗塞和血栓栓塞事件,影响生存率.
研究的目的:
- 确定急性白血病患者心血管并发症的危险因素.
- 为风险分层和监测策略提供信息.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 在多个数据库 (PubMed,Scopus等) 进行了搜索. 对于从2020年至2024年进行的研究.
- 包括75项分析AL患者心血管风险因素的研究,涉及亚型和治疗阶段.
主要成果:
- 心血管并发症是多因素的,受人口统计学,并发症 (高血压,糖尿病),治疗方法 (人环素,TKI,HSCT,辐射) 和遗传因素的影响.
- 心脏生物标志物 (热波宁,BNP),成像 (应变回声) 和心电图异常对于检测亚临床损伤至关重要.
- 在治疗期间和治疗后几年出现并发症,特别是在儿童和长期幸存者中.
结论:
- 在AL患者中,心血管并发症是常见的和严重的.
- 使用临床,遗传和生物标记数据的个性化,多学科的方法对于风险分层和监测至关重要.
- 改进的早期检测和预防策略可以改善患者的治疗结果.
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