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在F-PSMA-1007 PET/CT上的不同前列腺区域的放射特征用于预测前列腺癌患者的持续PSA:一项多中心研究

Licong Li¹, Jian Xu¹, Shuying Bian¹

¹The Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

|September 13, 2025

概括

在18F-PSMA-1007 PET/CT上的特定前列腺子区域的放射特征可以预测持续的前列腺癌. 将放射学模型与PSA模型相结合,可显著提高预测准确度.

科学领域:

放射学放射学是一门学科.
在瘤学瘤学.
医疗成像医学成像

背景情况:

治疗后的持续性前列腺癌是一个临床挑战.
准确预测持续性前列腺癌对于指导治疗决策至关重要.

研究的目的:

在18F-PSMA-1007 PET/CT上研究来自不同前列腺子区域的放射性特征 (RF) 的预测价值,以检测持续性前列腺特异性抗原 (PSA).
开发和验证放射学模型,单独和与PSA水平相结合,用于预测持久的PSA.

主要方法:

对354名局部性前列腺癌患者的回顾性分析.
前列腺细分为三个区域 (内部,周围,正常) 基于SUVmax在18F-PSMA-1007PET/CT.
开发了五种放射学模型和与PSA结合的模型,使用ROC曲线和AUC进行评估.

主要成果:

放射学模型 (模型-ip,模型-ipn,模型-intra) 在队列中显示了不同的预测性能.
整合模型-ip和PSA的组合模型实现了最高的AUC (0.78培训,0.78内部验证,0.89外部验证).

结论:

在18F-PSMA-1007 PET/CT上,来自不同前列腺子区域的放射学特征为持久性PSA提供了差异性预测能力.
一个结合放射学和PSA模型,特别是包含20-45%和45-100%的SUVmax区域,在预测持久PSA方面表现出更高的准确性.

关键词:

聚乙烯/聚乙烯/聚乙烯持续的PSA是一种持续的PSA.前列腺癌是前列腺癌.无线电学 (radiomics) 是一种无线电学.瘤微环境是一个微环境.

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