免疫疗法相关心脏毒性:目前的见解和准确心脏瘤学的未来方向
Eleni Stefanou1, Georgios Tsitsinakis2, Dimitra Karageorgou2
1Artificial Kidney Unit, General Hospital of Messinia, 24100 Kalamata, Greece.
Cancers
|September 13, 2025
概括
癌症免疫疗法提供了生存益处,但可以导致严重的心脏问题,如心肌炎. 个性化风险评估和早期检测对于管理这些与免疫相关的心脏不良事件至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 癌症免疫疗法彻底改变了瘤学,提高了恶性瘤的存活率.
- 尽管有好处,免疫疗法存在心血管不良事件的风险.
- 这些事件影响重要器官,需要仔细监测.
研究的目的:
- 审查癌症免疫疗法的心血管不良事件.
- 探索病理生理机制和管理策略.
- 评估针对风险减轻的个性化干预措施.
主要方法:
- 关于免疫治疗心脏毒性的综合文献综述.
- 对流行病学数据和病理生理机制的分析.
- 评估风险分层的新兴个性化策略.
主要成果:
- 免疫疗法与心肌炎,心力衰竭,心律失常和动脉样硬化有关.
- 免疫检查点抑制剂相关心肌炎的死亡率很高.
- 汽车T细胞治疗可以导致细胞因子释放综合征与心血管并发症.
结论:
- 癌症免疫疗法呈现出各种与免疫相关的心脏不良事件.
- 在治疗前,治疗期间和治疗后,个性化患者管理至关重要.
- 早期识别和个性化风险评估是控制心脏毒性的关键.
关键词:
节律失常 (arrhythmia) 是一种心律失常.人工智能的人工智能是人工智能.心脏毒性心脏毒性基因分析 基因分析心脏衰竭是因为心脏衰竭.与免疫相关的不良事件.免疫疗法 免疫疗法肌性心肌炎是一种心肌炎.更多相关视频
11:08Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
Published on: February 14, 2025
1.8K
14:24Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
Published on: January 21, 2018
12.1K
相关概念视频
Tumor Immunotherapy
1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
Combination Therapies and Personalized Medicine
5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
Cardiomyopathy V: Interprofessional Care
343
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
343
Cardiomyopathy I: Introduction and Classification
514
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
514
Cancer Vaccines
976
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
976
