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在血液恶性病的CAR-T细胞免疫疗法后的内皮损伤

Christos Demosthenous¹, Paschalis Evangelidis², Athanasios Gatsis²

¹BMT Unit, Hematology Department, George Papanicolaou General Hospital, 57010 Thessaloniki, Greece.

|September 13, 2025

概括

化学抗原受体-T (CAR-T) 细胞疗法可能会由于内皮损伤引起毒性. 监测内皮损伤标志物可能有助于预测严重的副作用,并改善CAR-T细胞接受者的患者结果.

科学领域:

免疫治疗是一种免疫疗法.
在瘤学瘤学.
血管生物学血管生物学

背景情况:

化学抗原受体-T (CAR-T) 细胞疗法是复发/耐药B细胞恶性瘤的重要治疗方法.
卡尔-T细胞疗法可能导致显著的毒性,包括细胞因子释放综合征 (CRS) 和免疫效应细胞相关的神经毒性综合征 (ICANS).
内皮细胞损伤是这些CAR-T细胞相关毒性背后的一个关键机制.

研究的目的:

审查正在接受CAR-T细胞治疗的患者内皮损伤的当前研究.
探索各种内皮损伤标志物在预测CAR-T细胞相关毒性的作用.
评估内皮细胞激活评分在患者管理中的潜力.

主要方法:

在CAR-T细胞治疗中对内皮损伤标记物的现有文献的综述.
对研究对补充激活标记物,内皮功能障碍,炎症和血栓形成的研究进行分析.
检查内皮细胞激活和压力指数 (EASIX) 和其修改版本.

主要成果:

与健康对照人群相比,CAR-T细胞接受者显示内皮损伤标志物的水平发生变化.
这些标记物的表达水平在严重毒性患者和轻度毒性或无毒性患者之间有所不同.
输注前和后评估的EASIX评分似乎可以预测严重的毒性和血液毒性.

结论:

内皮损伤是CAR-T细胞治疗毒性的重要因素.
特定的内皮损伤标志物和EASIX分数可以作为预测生物标志物.
需要进一步的研究,以充分阐明内皮损伤标记在CAR-T细胞治疗中的临床影响.

关键词:

在CART-T中,我们可以使用CAR-T.在CRS中,您可以使用CRS.在ICANS中,我们可以看到ICANS.补充补充补充补充补充补充补充.它们的内皮质 (endothelium).淋巴瘤淋巴瘤是什么骨髓瘤多样性骨髓瘤多样性

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