乳腺癌查中的人工智能驱动个性化:从人口模型到个性化协议
Filippo Pesapane1, Luca Nicosia1, Lucrezia D'Amelio2,3
1Breast Imaging Division, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy.
Cancers
|September 13, 2025
概括
人工智能 (AI) 通过改进风险模型来增强乳腺癌查个性化,但证据在亚型中混杂. 广泛采用需要证明临床益处并解决公平问题.
科学领域:
- 在瘤学瘤学.
- 医疗成像医学成像
- 人工智能的人工智能
背景情况:
- 目前基于年龄的乳腺癌查有局限性,包括过度诊断和错过的癌症.
- 风险分层查方法正在获得引力,以提高准确性和减少危害.
- 人工智能 (AI) 是推动个性化查进步的关键技术.
研究的目的:
- 审查人工智能在推进乳腺癌查方面的作用,以实现个性化的方法.
- 检查人工智能驱动的乳房扫描风险模型,多模式风险预测和临床决策支持工具.
- 评估目前的证据,挑战和人工智能在乳腺癌查中的未来方向.
主要方法:
- 对2015年至2025年发表的研究进行叙述性审查.
- 优先考虑大型队列,随机试验和前性验证.
- 专注于人工智能在乳腺造影风险建模,多式联络数据集成和临床决策支持方面的应用.
主要成果:
- 基于人工智能的乳房扫描风险模型显示,与传统模型相比,歧视有所改善,外部验证正在进行中.
- 对人工智能模型的证据在乳腺癌亚型中异质,对ER阳性疾病的信号更强烈.
- 综合多种数据类型和人工智能用于分拣/个性化间隔的多式模式正在出现.
- 障碍包括可解释性,监管批准和确保公平获取.
结论:
- 人工智能工具对个性化乳腺癌查,特别是乳房扫描风险评估充满希望.
- 需要进一步的前性试验来确认临床结果的好处,并指导个性化查间隔.
- 精心整合,监管调整,公平监测和明确的角色定义对于人工智能在选工作流程中的采用至关重要.
相关概念视频
02:50Combination Therapies and Personalized Medicine
5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K
02:53Adaptive Mechanisms in Cancer Cells
7.0K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.0K
01:21Cancer Survival Analysis
650
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
650
02:43Mouse Models of Cancer Study
6.4K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.4K