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用尿素重新组装的豆脂性蛋白纳米颗粒来输送白醇:结构,接口和消化

Mingming Zhong¹, Yufan Sun^1,2, Qayum Abdul¹

¹School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China.

Foods (Basel, Switzerland)

|September 13, 2025

概括

大豆脂性蛋白 (LP) 纳米颗粒有效封装复星 (Res),增强其界面特性和稳定性. 这些R-loaded LP纳米颗粒显示了改善的消化能力和持续释放,支持它们在营养输送系统中的使用.

科学领域:

食品科学与技术食品科学与技术
生物材料科学是生物材料的科学.
纳米技术纳米技术

背景情况:

大豆脂性蛋白 (LP) 是开发输送系统的有前途的生物材料.
复星 (Res) 是一种具有潜在健康益处但生物可用性有限的生物活性多.
基于纳米粒子的输送系统可以提高生物活性化合物的稳定性和生物可用性.

研究的目的:

为了研究含有复星的大豆脂友蛋白纳米粒子的结构,界面特性和体外消化能力.
探索尿素诱导的拆解-重组对LP纳米粒子特性的影响.
评估这些纳米颗粒作为营养应用中复星的纳米载体的潜力.

主要方法:

大豆脂性蛋白 (LP) 的尿素诱导的分解-重组.
将白醇 (Res) 封装成LP纳米粒子.
使用透析进行结构分析 (二级到四级结构).
界面特性和泡稳定性的表征.
在体外消化研究以评估持续释放和消化能力.

主要成果:

在透析过程中,LP结构可逆地重组.
在8M尿素 (8U-Res) 达到的最高封装效率 (88.32%) 和负载能力 (15.91μg/mg).
重装的LP-Res纳米粒子表现出更好的界面特征和泡稳定性.
8U-Res纳米颗粒显示持续释放和高体外消化率 (77.8%).

结论:

LP结构恢复与增强的界面功能密切相关.
含有白醇的LP纳米颗粒显示出作为有效的纳米载体的显著潜力,用于营养输送.
尿素诱导的拆卸-重新组装方法为创建功能化的LP基纳米载体提供了一种可行的方法.

关键词:

在体外消化过程中消化.油水接口油水接口复星醇是一种复星醇.大豆脂性蛋白质是大豆的脂性蛋白质.尿素诱导的重组.

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