父亲身体质量指数与神经发育-身体结果之间的关联在婴儿怀孕年龄小的儿童中
Yimin Zhang1, Shuming Shao1, Jiong Qin1
1Department of Pediatrics, Peking University People's Hospital, Beijing 100044, China.
Diagnostics (Basel, Switzerland)
|September 13, 2025
概括
父亲肥胖和体重不足与怀孕年龄小 (SGA) 儿童的不良结果有关,包括发育迟缓和肥胖风险. 在怀孕之前优化父亲的体重指数 (BMI) 可以改善儿童的健康.
科学领域:
- 生殖健康 生殖健康
- 儿科 儿科 儿科
- 发展生物学 发展生物学
背景情况:
- 父亲预先设想的体重指数 (BMI) 是影响后代健康的新兴因素.
- 怀孕年龄较小的婴儿面临长期身体和神经发育问题的风险增加.
- 父亲的BMI类别对SGA儿童的结果的具体影响需要进一步调查.
研究的目的:
- 检查父亲BMI类别 (体重不足,正常,超重,肥胖) 在受孕前与SGA儿童的身体和神经发育结果之间的关联.
- 在中国一组SGA儿童中,确定与不同父亲BMI层相关的特定风险.
主要方法:
- 在2020-2022年间出生的412个单独SGA婴儿的前性队列研究.
- 父亲被分为BMI组:体重不足,体重正常,超重和肥胖.
- 24-36个月后的后续评估包括生长参数 (体重,身高,BMI Z-分数) 和神经发育评估 (ASQ-3,ASQ:SE).
主要成果:
- 父亲体重不足与较低的出生体重和较高的严重SGA发病率有关.
- 父亲的肥胖与后代的BMI Z-score增加以及儿童肥胖风险增加8.7倍相关.
- 父亲体重不足和肥胖都与毛细运动障碍有关; 父亲肥胖也显示出解决问题的缺陷,以及社会情绪延迟的风险增加了3倍.
结论:
- 父亲的BMI与SGA后代的神经发育结果之间存在U形关系.
- 父亲肥胖显著增加后代肥胖和各种神经发育缺陷的风险.
- 父亲体重不足与严重的SGA和运动缺陷有关,这强调了父亲体重管理对于改善儿童健康结果的重要性.
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