相关实验视频

Updated: Jan 18, 2026

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

在肝细胞癌中免疫组织化学的更新

Bingyu Li¹, Larry Huang², Jialing Huang³

¹Department of Pathology, Icahn School of Medicine at Mount Sinai-Morningside/West, New York City, NY 10019, USA.

Diagnostics (Basel, Switzerland)

|September 13, 2025

概括

免疫组织化学 (IHC) 的进展有助于肝细胞癌 (HCC) 的诊断和治疗. 本综述详细介绍了IHC标志物,用于预测HCC患者的预后和免疫治疗反应.

科学领域:

在瘤学瘤学.
病理学病理学病理学
分子生物学分子生物学

背景情况:

肝细胞癌 (HCC) 对全球健康构成重大负担,因分子多样性和晚期检测而复杂化.
免疫组织化学 (IHC) 在诊断和管理HCC方面发挥着至关重要的作用,但最佳的标志物利用需要持续评估.

研究的目的:

综合审查最近的IHC在HCC诊断,预后和预测治疗反应方面的进展.
系统地评估HCC的传统和新兴IHC生物标志物,评估它们在不同瘤等级的诊断准确性.

主要方法:

系统评估已建立的IHC标记物 (HepPar1,Arg-1,GPC3) 和新生物标记物.
对预后标记物 (Ki-67,VEGF) 和免疫检查点标记物 (PD-L1,CTLA-4) 与患者的治疗结果和治疗反应相关的分析.
对不同差异化的HCC的诊断灵敏度和特异性的审查.

主要成果:

已经确立的标记物,如HepPar1,Arg-1和GPC3,在HCC诊断中具有实用性.
预后标志物 (Ki-67,VEGF) 表明与生存率下降的相关性,而免疫检查点标志物 (PD-L1,CTLA-4) 预测了晚期HCC的免疫治疗反应.
根据瘤分化,对标记物的敏感性和特异性有所不同.

结论:

在临床实践中优化IHC标记物的使用对于改善HCC管理至关重要.
需要进一步的研究,以解决生物标志物验证和标准化方面的知识差距,以实现一致的临床应用.
在HCC中,IHC具有个性化治疗策略的巨大潜力.

关键词:

诊断生物标志物生物标志物肝细胞癌 (HCC) 是一种肝细胞癌.免疫组织化学 (IHC)预测性的生物标志物预后标志物预后标志物

更多相关视频

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma

Published on: April 25, 2025

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

相关概念视频

Immunocytochemistry and Immunohistochemistry

Immunocytochemistry and Immunohistochemistry

Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
These...