临床前用水介导的超声波平台使用临床视野进行分子向对比增强超声波
Stavros Melemenidis1, Anna Stephanie Kim1,2, Jenny M Vo-Phamhi1,3
1Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Diagnostics (Basel, Switzerland)
|September 13, 2025
概括
研究人员开发了一种低成本的3D动态对比增强超声波 (DCE-US) 平台,用于整个腹部小鼠成像. 这种方法可以在临床前研究中对瘤和器官进行详细的分子和血管分析.
科学领域:
- 生物医学成像技术 生物医学成像技术
- 临床前研究 临床前研究
- 超声波技术 超声波技术 超声波技术
背景情况:
- 临床前超声波系统往往缺乏实时体积和分子成像能力.
- 现有的系统在小型动物模型中对全腹部综合分析存在局限性.
研究的目的:
- 建立一个低成本的标准化协议,用于小鼠全腹部3D动态对比增强超声波 (DCE-US) 成像.
- 通过允许体积和分子成像来解决临床前超声波的局限性.
主要方法:
- 在EPIQ 7系统上使用临床矩阵阵列传感器 (X6-1).
- 开发了一种经过修改的杯和水浴,用于在体内对患有双重皮下瘤的小鼠进行成像.
- 在多个时间点进行对照增强的3D成像的目标微泡.
主要成果:
- 在一次扫描中实现了瘤和周围解剖学的高分辨率,对比模式的3D成像.
- 通过时间强度曲线和差异向增强 (DTE) 分析,在被辐射的瘤中显示出更大的微泡吸收.
- 微泡吸收增加与瘤中P-选择素表达升高相关.
结论:
- 开发的平台可以在临床前研究中实现全腹部分子DCE-US.
- 便于在不同病变或器官中进行血管和分子特征的动物内部比较.
- 为先进的临床前超声波研究提供了一种标准化的方法.
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