妊娠糖尿病和妊娠并发症中的炎症标志物和遗传变异:一个横截面研究
Jelena Omazić1,2, Andrijana Muller3,4, Mirta Kadivnik3,4
1Department of Laboratory Diagnostic, "Dr. Juraj Njavro" National Memorial Hospital, 32000 Vukovar, Croatia.
Diagnostics (Basel, Switzerland)
|September 13, 2025
概括
孕期糖尿病 (GD) 涉及炎症,复杂病例中IL-6较高. 某些IL-6和阿迪波涅丁基因变异可能会略微增加GD风险,但整体关联很弱,表明原因复杂.
科学领域:
- 生殖生物学和免疫学
- 遗传学和个性化医学
- 妊娠中的代谢障碍 妊娠中的代谢障碍
背景情况:
- 孕期糖尿病 (GD) 是一种与炎症相关的常见妊娠并发症.
- 肥胖是GD的一个关键风险因素,与高的促炎标志物 (TNF-α,IL-6) 和降低的抗炎标志物 (IL-10,皮内克丁) 相相关.
- 了解炎症标志物,它们的遗传变异和GD风险之间的相互作用对于有针对性的干预至关重要.
研究的目的:
- 为了研究妊娠糖尿病中炎症因素 (IL-6,TNF-α,IL-10,阿迪波涅丁) 和它们的遗传变体 (rs1800629,rs1800796,rs1800896,rs266729) 之间的关联.
- 分析这些因素在一个独特的四组研究设计涉及孕妇.
- 探索炎症标志物水平和特定基因变异之间的潜在相关性.
主要方法:
- 血液样本从162名怀孕妇女的第三季度收集.
- 测量了IL-6,IL-10,TNF-α和阿迪波内克丁的水平.
- 实时PCR用于基因类型选择单核酸多态 (SNP).
主要成果:
- 在孕妇患有GD和额外并发症 (p < 0.001) 的情况下,观察到显著更高的IL-6水平.
- 在IL-6 SNP rs1800796异体CG基因型中,GD风险略有增加 (OR = 1.41).
- 阿迪波Q rs266729同卵性CC基因型与增加GD风险相关 (p = 0.03). 对于TNF-α rs1800629或IL-10 rs1800896SNP没有发现显著的关联.
结论:
- 孕期糖尿病怀孕有额外的并发症表现出更大的炎症负担.
- 特定的IL-6和AdipoQ基因变异可能导致GD易感性.
- 炎症标志物和基因变异之间的弱整体关联凸显了GD的多基因性质,环境影响和潜在的样本大小限制.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Pathophysiology of Diabetes
3.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.2K
Genome-wide Association Studies-GWAS
15.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.3K
Human Genetics
1.5K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.5K
Coronary Artery Disease I: Introduction
890
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
890


