在复发性复发性硬化症中,OCT和VEP参数与残疾和疾病持续时间之间的关系
Manuela Andreea Ciapă1, Vlad Constantin Donica2, Claudia Florida Costea2
1Doctoral School, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, No. 16, 700115 Iasi, Romania.
Diagnostics (Basel, Switzerland)
|September 13, 2025
概括
光学连贯断层扫描 (OCT) 和视觉唤起潜能 (VEP) 揭示了多发性硬化症 (MS) 患者的结构和功能损伤. 海外和海外国家的测量与疾病持续时间和残疾相关,增强神经退行评估.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 神经学 神经学
背景情况:
- 视神经炎 (ON) 是多发性硬化症 (MS) 相关的中枢神经系统脱髓化的关键指标.
- 光学连贯断层扫描 (OCT) 和视觉唤起潜能 (VEP) 是评估视觉通路损伤的关键非侵入性工具.
研究的目的:
- 在有或没有ON病史的MS患者中对OCT和VEP参数进行相关联.
- 评估这些参数,疾病持续时间和残疾之间的关系 (EDSS).
主要方法:
- 对27名复发性复发性多发性硬化症患者 (54只眼睛) 的横截面研究.
- 通过OCT测量了视网膜神经纤维层 (pRNFL) 和质细胞内状层 (GCIPL) 的厚度.
- VEPs评估了P100的延迟和幅度.
主要成果:
- 没有ON病史的眼睛显示显著更厚的prnfl和gcipl.
- 虽然没有统计学意义,但非ON眼睛的P100延迟时间较短,幅度更高.
- OCT厚度与EDSS和疾病持续时间有负相关性;P100延迟与OCT参数有负相关性.
结论:
- 海洋和海上国家/地区的参数 (pRNFL,GCIPL) 与MS的临床标志物和功能状态相关.
- 结合的OCT和VEP评估改善了对MS神经退行和疾病进展的评估.
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