单边肺激应:流行率,解剖学变体和临床影响的系统审查
Mathias Orellana-Donoso1,2, Mariano Barrenechea-Salvador1, Joaquín Caro-Navarro1
1Escuela de Medicina, Universidad Finis Terrae, Santiago 7501015, Chile.
Diagnostics (Basel, Switzerland)
|September 13, 2025
概括
单侧肺生代 (ULA) 是一种罕见的先天性疾病. 这次审查发现右侧的ULA更常见,结果更差,突出了早期诊断和多学科护理的需要.
科学领域:
- 医学遗传学和发育生物学
- 儿科肺病学 儿科肺病学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 单侧肺生代 (ULA) 是一种罕见的先天性异常,涉及一个肺的完全缺失.
- 乌拉经常出现相关的心血管,骨或胃肠道形,使其临床管理复杂化.
- 关于ULA患病率,解剖学变异和患者结局的现有数据是分散的,需要进行全面的综合分析.
研究的目的:
- 系统地审查和综合当前关于单边肺细胞发生率的证据.
- 分析与ULA相关的解剖学分类,诊断方式和临床影响.
- 为患有ULA的患者提供有关预后和管理策略的见解.
主要方法:
- 在五个主要数据库 (MEDLINE,科学网,CINAHL,Scopus,EMBASE) 进行了系统的文献搜索,截至2024年1月,遵守PRISMA 2020指南.
- 纳入标准侧重于关于人类ULA的病例报告,病例系列和观察性研究.
- 使用乔安娜·布里格斯研究所 (JBI) 检查清单来评估偏差风险,并由于研究异质性而采用叙事综合.
主要成果:
- 审查包括了32项涉及137名参与者的研究.
- 右侧的ULA更为普遍 (58%) 并与更差的预后相关,通常是由于中椎扭曲;心血管异常是最常见的并发症 (40%).
- 胸部放射 (85%),CT扫描 (70%) 和支气管镜 (25%) 是主要的诊断工具;施耐德-博伊登尺度被用于分类.
结论:
- 单边肺生代需要多学科的方法,特别是当相关的异常存在时.
- 左侧的ULA通常与更好的结果相关,这强调了早期诊断成像的重要性.
- 未来的研究应该优先考虑标准化分类和纵向研究设计,以提高ULA管理的证据质量.
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