通过从Sambucus ebulus L.水果中选择的多来调节内质网膜应激
Stoyan Stoyanov1, Momchil Barbolov2, Galina Yaneva1
1Department of Biology, Faculty of Pharmacy, Medical University of Varna, 84 Tzar Osvoboditel Blvd., 9002 Varna, Bulgaria.
Plants (Basel, Switzerland)
|September 13, 2025
概括
本综述探讨了桑布库斯 ( Sambucus ebulus L.) 果实中的植物化学物质如何影响内分泌网膜 (ER) 应激. 某些化合物,如白醇,可能为与慢性细胞压力相关的疾病提供治疗益处.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 由蛋白质错误折叠引起的内质网膜 (ER) 压力与各种疾病有关.
- 桑布库斯 (Sambucus ebulus L.) 果的水性提取物具有抗炎性质,可能通过降低ER压力.
- 在提取物中鉴定出的关键植物化学物质包括新基酸,基酸,伊达因,甲,复星和香胺.
研究的目的:
- 审查Sambucus ebulus L.果实中发现的特定植物化学物质对细胞内膜网膜 (ER) 应激的影响.
- 确定这些植物化学物质在管理与细胞压力相关的疾病中的潜在治疗应用.
主要方法:
- 在PubMed和ScienceDirect的文献搜索数据库中搜索ER压力标志物和选定的植物化学物质的研究.
- 选择和审查42篇相关的初级研究文章.
- 分析植物化学物质与ER应力调节之间的关联,特别是PERK通路.
主要成果:
- 有限的数据存在于neochlorogenic酸和idaein关于ER压力.
- 聚醇在低度下,在各种实验模型中通常会降低ER压力标志物.
- 高剂量的白醇在癌症细胞系中表现出前性作用.
- PERK途径与这些化合物的观察到的效果有显著的关联.
结论:
- 审查的多和ER应力调节之间存在联系.
- 虽然需要进一步的研究,但这些植物化学物质在涉及慢性细胞应激的条件下显示出治疗用途的希望.
- PERK通路是这些植物化学物质和ER压力之间的相互作用的关键调解者.
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