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基于富含安东素的米粉的可扩展胃膜,可改善酸的输送

Nattawipa Matchimabura¹, Jiramate Poolsiri¹, Nataporn Phadungvitvatthana¹

¹Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla 90112, Thailand.

|September 13, 2025

概括

这项研究开发了使用大米粉来增强酸 (FA) 输送的新型可扩展的胃膜. 霍姆尼尔米粉膜显示出优异的抗氧化和抗炎作用,改善了FA的生物可用性.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
生物化学生物化学

背景情况:

酸 (FA) 具有显著的抗氧化和抗炎性质,但具有较差的水溶性,限制了其治疗用途.
开发有效的药物输送系统对于克服FA的生物可用性挑战至关重要.

研究的目的:

制定和描述可扩展的胃膜,以增强酸 (FA) 的输送.
为了评估FA的抗氧化和抗炎潜力,通过米粉基薄膜输送.

主要方法:

使用Eudragit® EPO.制备了酸固体分散剂 (FA-SD).
可扩展的胃膜是使用Hom-Nil大米,质大米或白米粉,素和基甲基纤维素 (HPMC) 通过溶剂造来制造的.
评估了薄膜特性,FA释放动力学,抗氧化剂和抗炎活性.

主要成果:

通过FA-SD实现了FA可溶性的24倍增加.
最佳的片表现出有利的机械性能,胀和展开行为.
含有HPMC和Hom-Nil或质米粉的薄膜在8小时内持续释放FA.
基于Hom-Nil大米粉的薄膜在RAW 264.7细胞中表现出优异的抗氧化和抗炎活性,与自由FA和FA-SD相比.

结论:

富含安东素的色素米粉的可扩展薄膜是有效的胃养系统,用于增强FA输送.
这些新的片显著提高了FA的生物可用性和治疗疗效.
开发的薄膜对治疗需要强大的抗氧化和抗炎干预措施的疾病具有前景.

关键词:

基多酸盐的使用方法可扩展薄膜可以扩展.铁酸是什么意思铁酸是什么意思胃营养的载体胃营养的载体米粉米粉是一种

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