相关实验视频

Updated: Jan 18, 2026

Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay
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Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay

Published on: August 26, 2018

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在多发性硬化症患者大脑样本的转录组中进行替代分离的系统分析.

Müge Sak1, Julia H Chariker1, Eric C Rouchka2

  • 1Kentucky IDeA Networks of Biomedical Research Excellence Data Science Core, Department of Neuroscience Training, University of Louisville, Louisville, KY 40292, USA.

International journal of molecular sciences
|September 13, 2025
PubMed
概括

替代拼接是基因表达的一个关键过程,在多发性硬化症 (MS) 的进展中起着关键作用. 我们的研究揭示了在MS中由替代拼接驱动的明显的分子差异,为这种复杂的神经系统疾病提供了新的见解.

关键词:
在RNA-seqqq.另一个替代拼接方法是拼接.不同的表达方式,不同的表达方式.多发性硬化症多发性硬化症

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相关概念视频

Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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