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Updated: Jun 19, 2026

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
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具有推拉架构的2-基诺林作为具有神经特性的β-粉样聚合的传感器

Marta Piquero1, Álvaro Sarabia-Vallejo1, Latoya Bote-Matías2

  • 1Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.

International journal of molecular sciences
|September 13, 2025
PubMed
概括

新的近红外发射光探针被合成来检测粉样蛋白质. 这些探头可视化阿尔茨海默氏症患者的β-粉样斑块.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.贝塔胺聚合物 贝塔胺聚合物光传感器 光传感器神经保护神经保护蛋白质病变是一种蛋白质病变.他们是天文学家.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...