研究提取物的神经保护性,肝保护性和抗菌作用
Menna-Allah E Abdelkader1,2, Hatungimana Mediatrice1,3, Zhanxi Lin1
1China National Engineering Research Center of Juncao Technology, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
International journal of molecular sciences
|September 13, 2025
概括
药用如Ganoderma lucidum和Hericium erinaceus提供神经保护和肝脏保护的好处,打击衰老的影响. 提取物还显示出抗菌性质,支持整体健康,并可能减少与年龄相关的衰退.
科学领域:
- 菌类学和药理学 菌类学和药理学
- 生物化学和分子生物学
- 衰老研究研究 衰老研究
背景情况:
- 含有丰富的生物活性化合物,具有抗氧化和抗衰老潜力.
- 衰老与细胞功能障碍有关,特别是受损的自.
- 药用因其促进健康的特性而受到探索.
研究的目的:
- 研究四种提取物的神经保护性,肝保护性和抗菌作用.
- 评估提取物对衰老标志物和相关基因表达的影响.
- 评估作为人类健康的天然剂的潜力.
主要方法:
- 提取和植物化学分析 (蛋白质,类,黄类) 光,Hericium erinaceus,Pleurotus ostreatus,和Agaricus bisporus. 这三种植物.
- 在使用D-银糖的模型中诱导衰老,然后用提取物进行治疗.
- 评估肝功能 (GOT,GPT),肝脏和大脑组织的组织病理学,以及与神经退行相关的基因表达 (SEPT5-SV2B-ATXN2-PARK2),端粒长度和炎症 (IL-2,IL-4,IL-6).
- 使用阿加井扩散和最小抑制度 (MIC) 测定对Lysinibacillus odyssey,Lysinibacillus fusiformis,Klebsiella oxytoca和Escherichia coli进行抗菌活性测试.
主要成果:
- 所有的提取物都减轻了氧化应激;Agaricus bisporus含有高蛋白质/黄类,Pleurotus ostreatus含有高类.
- 黑 (Hericium erinaceus) 和光 (Ganoderma lucidum) 显示出显著的神经保护和肝脏保护,防止D-银糖诱导的衰老.
- 提取物减少了肝酶 (GOT,GPT) 和调节的免疫反应 (上调的IL-2,IL-4;下调的IL-6).
- 羊显著提高了与神经退行相关的基因 (SEPT5,SV2B) 和端粒长度的调节.
- 所有的提取物都显示出抗菌活性,其中Agaricus bisporus对Lysinibacillus odyssey和Hericium erinaceus对大肠杆菌有效.
结论:
- 可食用和药用具有重要的神经保护性,肝脏保护性和抗菌性质.
- 黑 (Hericium erinaceus) 和白 (Ganoderma lucidum) 显示出对抗与年龄相关的衰退和神经退行症的有希望.
- 提取物可以调节炎症通路,并表现出广泛的抗菌活性.
- 这些发现支持使用作为促进健康和抗衰老的天然剂.
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