动脉样硬化中的肠道微生物群衍生代谢物:途径,生物标志物和点
Alexandra-Kristine Tonch-Cerbu1,2, Adrian-Gheorghe Boicean1,2, Oana-Maria Stoia1,2
1Medical Clinical Department, Faculty of Medicine, "Lucian Blaga" University, 550024 Sibiu, Romania.
International journal of molecular sciences
|September 13, 2025
概括
肠道微生物群通过像TMAO这样的微生物代谢物影响动脉样硬化. 通过饮食或FMT准肠心轴为心血管健康提供了潜在的治疗策略.
科学领域:
- 微生物学 微生物学
- 心血管科学 心血管科学
- 代谢学 代谢学 代谢学
背景情况:
- 人的肠道微生物群在宿主新陈代谢,免疫力和心血管健康方面发挥着至关重要的作用.
- 肠道微生物不平衡,即肠道微生物不平衡,与动脉样硬化的发展和进展有关.
- 系统循环的微生物代谢物调解肠心轴,影响血管和免疫功能.
研究的目的:
- 审查肠道微生物群和动脉样硬化之间的机制,诊断和治疗联系.
- 突出肠心轴的既定发现和新兴研究方向.
- 讨论微生物代谢物的作用作为生物标记物和心血管疾病的治疗点.
主要方法:
- 关于肠道微生物群和动脉样硬化的当前研究的文献综述.
- 对已确定的和新出现的微生物代谢物 (TMAO,LPS,SCFA,胆酸,酸等) 的分析. ) 的情况.
- 评估微生物生物标志物和治疗干预措施 (饮食,益生菌,FMT,药理方法) 的诊断潜力.
主要成果:
- 三甲基胺N氧化物 (TMAO) 是一个关键的代谢物,与心血管事件始终相关.
- 其他代谢物如LPS,SCFA和胆酸调节炎症,内皮功能和脂质代谢.
- 微生物生物标志物具有预测价值,但由于变异性和缺乏标准化而面临限制.
结论:
- 肠道微生物群通过各种代谢物显著影响动脉样硬化.
- 微生物代谢物是评估心血管风险的有希望的生物标志物.
- 针对肠心轴的干预措施,包括饮食改变和FMT,显示出对动脉样硬化的治疗潜力.
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