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磁纳米颗粒在医学中的毒性:贡献因素和现代评估方法

Julia Nowak-Jary¹, Beata Machnicka¹

¹Department of Biotechnology, Institute of Biological Sciences, University of Zielona Gora, Prof. Z. Szafrana 1, 65-516 Zielona Gora, Poland.

International journal of molecular sciences

|September 13, 2025

概括

磁铁氧化物纳米粒子 (MNPs) 在医学上表现有前途,但需要进行彻底的毒性评估. 研究强调了纳米粒子特性和测试方法的影响,包括新的方法,用于安全的临床使用.

科学领域:

生物医学纳米技术生物医学纳米技术
纳米毒理学研究
材料科学材料科学材料科学

背景情况:

磁性氧化铁纳米粒子 (MNPs),如Fe3O4和γ-Fe2O3,由于其独特的磁性和表面特性,越来越多地用于生物医学.
应用包括MRI,药物输送,高温和治疗术,但它们的临床翻译取决于确保生物相容性和安全性.

研究的目的:

审查目前对MNP毒理学概况的理解.
强调物理化学性质和操作因素对MNP毒性的影响.
讨论传统和新型毒性评估方法的整合.

主要方法:

对MNP的体外,外生和体内毒性测试策略的审查.
分析MNP特征 (形态,表面变化,电荷) 如何影响毒性.
探索新方法方法 (NAM),如有机体,3D生物打印和卵子测试.

主要成果:

MNP的毒性受到大小,形状,表面化学,剂量和施用途径等因素的显著影响.
传统的毒性测试提供了基础数据,但存在局限性.
NAM为评估MNP安全提供了更具道德性,与人类相关性和预测性的替代方案.

结论:

对MNP进行全面的毒性评估需要将传统方法与先进的NAM整合起来.
了解MNP特性和生物反应之间的相互作用对于安全的纳米药物开发至关重要.
仔细评估物理化学和操作因素对于将MNP潜力转化为临床现实至关重要.

关键词:

在3D生物打印中使用3D生物打印图像化细胞计量图像化细胞计量图像化细胞计量在 ovo 方法中.在体外和体内有机毒性评估评估.磁铁氧化物纳米粒子磁铁氧化物纳米粒子纳米医药是一种纳米医药.的纳米毒性.有机生物有机物

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