相关实验视频

Updated: Jan 18, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

结肠直肠癌中的微RNA-潜在的诊断和预后标志物-最新的审查

Weronika Pająk¹, Jakub Kleinrok¹, Joanna Pec²

¹Department of Forensic Medicine, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.

International journal of molecular sciences

|September 13, 2025

概括

微RNAs (miRNAs) 显示为结直肠癌 (CRC) 查,诊断和治疗的生物标志物. 需要进一步的研究,才能充分了解它们在治疗这种致命疾病中的临床应用.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

结肠直肠癌 (CRC) 是全球癌症相关死亡的主要原因.
晚期诊断CRC使治疗复杂化,并使患者的结果恶化.
微RNAs (miRNAs) 越来越多地被认为是它们在癌症发展中的调节作用.

研究的目的:

探索微RNAs (miRNAs) 作为结直肠癌 (CRC) 的生物标志物的潜力.
审查miRNAs在CRC病原和进展中的参与.
讨论miRNAs在CRC查,诊断,预后和治疗选择中的临床应用.

主要方法:

对调查结直肠癌中microRNAs的研究进行文献综述.
对miRNA参与EMT,增殖,迁移,亡和自等关键癌症过程的分析.
检查miRNAs在CRC管理中的当前和潜在的临床应用.

主要成果:

微RNAs (miRNAs) 可以作为瘤抑制剂或结直肠癌 (CRC) 的瘤基因.
毫米RNAs显著影响CRC涉及的关键细胞过程,包括上皮细胞-介质细胞过渡 (EMT).
在CRC患者中,MiRNA显示出作为预测和预后生物标志物的潜力.

结论:

微RNAs (miRNAs) 具有改善结直肠癌 (CRC) 查,诊断和预后的巨大潜力.
它们在调节基因表达中的作用为CRC的个性化治疗策略提供了机会.
持续的研究对于充分利用miRNAs在临床瘤学中的治疗和诊断能力至关重要.

关键词:

结肠直肠癌是什么意思诊断标记物诊断标记物诊断标记物这是一个微型RNA.预后标志物预后标志物

更多相关视频

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...