内源性乙醇代谢和MASLD-MASH的发展
Núria Farràs Solé1, Sander Wydh1, Amir Hossein Alizadeh Bahmani1
1Department of Experimental Vascular Medicine, Amsterdam UMC, 1105 AZ Amsterdam, The Netherlands.
International journal of molecular sciences
|September 13, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与产生乙醇的肠道微生物有关. 这篇评论探讨了微生物乙醇合成,肝脏清除和基于微生物组的MASLD治疗方法.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是与代谢问题和炎症相关的日益严重的健康问题.
- 人们越来越认识到肠道微生物组在MASLD中的作用,特别是其从食糖中生产乙醇.
- 肠道微生物的内源性乙醇生产是MASLD病变发生的一个新型因素.
研究的目的:
- 审查当前对肠道微生物组对MASLD的贡献的理解.
- 探索微生物乙醇合成途径及其对肝脏健康的影响.
- 讨论针对MASLD的潜在基于微生物组的治疗策略.
主要方法:
- 关于MASLD肠道微生物组组成和功能研究的文献综述.
- 微生物代谢途径的分析,重点关注乙醇生产和发酵.
- 检查肝脏乙醇代谢和排毒机制.
- 审查当前和新兴的微生物组调节疗法.
主要成果:
- MASLD与肠道微生物组组成和功能的特定变化有关.
- 肠道微生物发酵食成分以产生内源性乙醇,有助于肝脏病理.
- 肝脏清除受损和微生物乙醇生产加剧了MASLD.
- 基于微生物组的干预措施显示出对管理MASLD的前景.
结论:
- 肠道微生物组在MASLD的发展和通过乙醇生产的进展中发挥着重要作用.
- 准微生物乙醇合成为MASLD提供了一个新的治疗途径.
- 对微生物群-肠-肝轴相互作用的进一步研究对于开发有效的MASLD治疗至关重要.
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