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显微镜下的MASLD:微RNA和微生物群如何塑造肝脏代谢疾病的进展

Clelia Asero^1,2, Maria Stella Franzè^1,2, Irene Cacciola^1,2

¹Division of Medicine and Hepatology, University Hospital of Messina, 98124 Messina, Italy.

International journal of molecular sciences

|September 13, 2025

概括

与代谢功能障碍相关的脂肪性肝病 (MASLD) 涉及肠道微生物群和微RNA (miRNAs). 本综述探讨了它们在MASLD进展中的表观遗传交叉以及分析潜在的AI应用.

科学领域:

肝病学肝病学是一种肝病学.
微生物学微生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 是全球慢性肝病的主要原因.
它的复杂病原发生涉及遗传,环境和并发症因素.
人们越来越认识到肠道微生物群在MASLD向脂肪肝炎 (MASH) 和癌症的进展中的作用,可能是通过微RNA (miRNA) 介导的表观遗传变化.

研究的目的:

通过MASLD中的miRNA表达来探索宿主和肠道微生物群之间的表观遗传交叉.
确定涉及MASLD发展和进展的特定途径.
评估人工智能应用程序来分析宿主微生物群相互作用和建模代谢性肝病中的表观遗传变化.

主要方法:

文献综述侧重于宿主微生物群相互作用,miRNA调节和MASLD中的表观遗传修饰.
对外体和外膜囊泡介导通信的新兴证据的分析.
探索用于数据分析和建模的人工智能工具.

主要成果:

新出现的数据表明,肠道微生物群和宿主之间通过miRNAs进行双向通信.
特定的miRNA和途径与MASLD的病原和进展有关.
人工智能为标准化微生物群评估和建模表观遗传变化提供了潜力.

结论:

由miRNAs介导的表观遗传交叉对MASLD的发病和进展起着重要作用.
了解这些宿主微生物群相互作用对于开发新型治疗策略至关重要.
人工智能有望促进对代谢性肝病中复杂相互作用的研究.

关键词:

人工智能的人工智能是人工智能.外基因组是外基因组的组成部分.与代谢功能障碍相关的脂肪性肝病.微RNAs 是一个微型RNA.我们的微生物群.

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