糖尿病对中角膜厚度值的影响:系统性审查和元分析
Arda Uzunoglu1, Juan José Valenzuela-Fuenzalida2,3, Karin Morales-Calderón2
1Republic of Turkey Ministry of National Education, Kocaeli 06420, Türkiye.
International journal of molecular sciences
|September 13, 2025
概括
糖尿病 (DM) 增加了中枢角膜厚度 (CCT),特别是在疾病持续时间较长和血糖控制不佳 (HbA1c) 的情况下. 在糖尿病患者中,CCT可能表明角膜变化.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 糖尿病是一种慢性代谢疾病,已知有系统和眼部并发症.
- 中央角膜厚度增加 (CCT) 是DM的眼部并发症,可能会影响内皮功能和眼部疾病风险.
研究的目的:
- 为了确定DM对CCT的影响.
- 评估CCT,糖尿病持续时间和糖化血红蛋白 (HbA1c) 水平之间的相关性.
主要方法:
- 在糖尿病患者中评估CCT的观察性研究的系统文献搜索.
- 使用随机效应模型进行元分析.
- 评估统计异质性和出版偏差.
主要成果:
- 与对照组相比,糖尿病患者的CCT显著更高.
- 长期的DM和低血糖控制 (HbA1c升高) 与CCT增加有关.
- CCT显示与疾病持续时间和HbA1c水平存在正相关性.
结论:
- 在患有长期疾病和血糖控制不足的糖尿病患者中,CCT增加.
- CCT评估可以作为糖尿病患者角膜变化的潜在指标.
相关概念视频
Pathophysiology of Diabetes
3.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.2K
Diabetes Mellitus: Overview and Type I Subtype
4.9K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.9K
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Diabetes: Symptoms, Diagnosis, and Complications
2.1K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.1K
Diabetes: Management and Pharmacotherapy
868
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
868
Coronary Artery Disease I: Introduction
890
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
890


