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Updated: Jan 18, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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在黑色素瘤进展中SPARC过度表达的调节机制

Antònia Vinyals1,2, Josep R Ferreres1,3, Rafael Campos-Martín4

  • 1TGF-β and Cancer Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.

International journal of molecular sciences
|September 13, 2025
PubMed
概括

黑色素瘤的进展涉及增加的SPARC表达,由转录因子PRRX1和TCF7L2-Sp1.1驱动. 微RNA miR-29b1~a微调SPARC水平,影响黑色素瘤细胞表型和转移.

关键词:
在EMT中,EMT是EMT.这就是PRRX1的原因.这就是SPARC的目的.这就是Sp1 Sp1 Sp1 的意思.在TCF7L2中使用.这是皮肤黑色素瘤.这就是为什么miR-29是miR-29的.

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