TSH水平与精神分裂症之间是否存在联系? 一个系统的审查和元分析
Elisa Gatta1,2, Francesco Dondi3, Ilenia Pirola1,2
1Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, 25121 Brescia, Italy.
Journal of clinical medicine
|September 13, 2025
概括
这项研究发现,精神分裂症患者和健康人群之间的甲状腺刺激激素 (TSH) 水平没有显著差异. 几十年来对TSH和精神分裂症的研究产生了不一致的结果,但这次元分析澄清了当前的证据.
科学领域:
- 神经内分泌学神经内分泌学
- 精神病学是一个精神病学.
- 临床研究 临床研究
背景情况:
- 甲状腺功能障碍和精神疾病经常同时发生,这表明存在潜在的联系.
- 由于研究结果不一致,甲状腺刺激激素 (TSH) 和精神分裂症之间的关系仍然不清楚.
- 研究精神分裂症中的TSH水平对于理解潜在的病理生理机制至关重要.
研究的目的:
- 系统地审查和分析现有研究,以确定TSH水平是否在精神分裂症患者和健康对照人群之间存在差异.
- 评估TSH水平对精神分裂症精神病现象的影响.
主要方法:
- 在PubMed/MEDLINE,Scopus和Web of Science数据库中进行了全面的系统搜索,直到2025年5月.
- 根据PICO框架选择了研究,重点关注TSH水平在第一发作中,以前没有服用过药物的精神分裂症患者与健康受试者.
- 遵循PRISMA指南,并使用QUADAS-2评估研究质量/偏差风险.
主要成果:
- 分析包括35项研究,包括3669名精神分裂症患者和1391名健康对照.
- 发现TSH水平在精神分裂症患者和对照人群之间是相似的 (SMD = -0.059 mIU/L).
- 在包括的研究中观察到实质性的异质性 (I2 = 84%,p < 0.001).
结论:
- 这一元分析得出结论,TSH水平与精神分裂症之间没有显著的关联.
- 尽管有广泛的研究和方法差异,但目前的证据并不支持TSH水平与精神分裂症之间的联系.
- 可能需要进一步的研究来探索其他潜在的生物标志物或精神分裂症的病因因素.
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