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卵巢刺激和触发协议对卵细胞和胚胎数量的影响-现实世界经验

Shmuel Somer¹, Simon Nothman², Shira Baram^3,4

¹Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.

Journal of clinical medicine

|September 13, 2025

概括

使用复合hCG和GnRH激动剂的双触发疗法,与单独复合hCG相比,在辅助生殖技术 (ART) 周期中显著提高卵细胞和胚胎产量. 这种方法通过增加检索的卵细胞和胚胎的数量来提高ART结果.

科学领域:

生殖内分泌学生殖内分泌学
在体外受精过程中受精.
艺术成果艺术成果

背景情况:

GnRH对抗剂协议在辅助生殖技术 (ART) 中被广泛使用.
卵细胞成熟和检索是影响ART成功的关键步骤.
正在探索双触发器策略以优化ART结果.

研究的目的:

为了比较双触发疗法 (复合hCG[rhCG] + GnRH激动剂) 与单独的rhCG在接受GnRH对抗剂方案的妇女中的疗效.
评估双触发器治疗对关键ART结果的影响,包括卵细胞产量和胚胎发育.
评估双触发器治疗在改善受精率方面的有效性.

主要方法:

回顾性单中心队列研究分析了1291次试管婴儿周期 (2016-2022年).
使用倾向分数匹配 (PSM) 来创建可比的组 (每组395个周期).
主要结局:获得的卵子总数;次要结局:成熟的卵子,受精率,胚胎数量.

主要成果:

与单独使用rhCG相比,双触发疗法显著增加了总卵细胞 (7.50对6.12) 和成熟卵细胞 (5.67对5.01).
在双触发组中观察到没有卵细胞检索的周期较少 (1.3%对3.8%).
双触发 (2.43对2.00) 的胚胎总数较高,ICSI周期中的受精率有所改善 (64.93%对52.22%).

结论:

双触发疗法通过增加卵细胞和胚胎产量显著提高ART结果.
这一策略为接受GnRH抗剂协议的妇女提供了潜在的改善.
进一步的研究可能会探索为各种患者群体优化双触发协议.

关键词:

在这个过程中,IVF IVF.双重触发器的触发器是一个双重触发器.双触发器的双触发器可以使用.胚胎的数量胚胎的数量卵子细胞的数量触发协议的触发协议.

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