肝细胞癌的碳离子放射治疗:当前状况和未来前景:叙述性审查
Reina Sasaki-Tanaka1, Hiroyuki Abe1, Tomoaki Yoshida1
1Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-9510, Japan.
Journal of clinical medicine
|September 13, 2025
概括
碳离子放射治疗 (C-离子RT) 在治疗肝细胞癌 (HCC),特别是较大的瘤方面表现出色. 这种放射治疗耐受性很好,提供了一个有前途的选择,副作用较少.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 肝细胞癌 (HCC) 是一种放射敏感的恶性瘤.
- 在当前的HCC治疗指南中,外部光束辐射疗法未得到充分利用.
- 碳离子放射治疗 (C-ion RT) 是一种先进的外部光束疗法.
研究的目的:
- 审查碳离子放射治疗 (C-离子RT) 对肝细胞癌 (HCC) 的疗效和安全性.
- 突出C离子RT作为HCC的治疗选择.
- 讨论C-ion RT在HCC管理中的指示和结果.
主要方法:
- 对C-离子RT对HCC的现有文献进行叙述性审查.
- 分析患者的耐受性,说明和不良事件.
- 评估局部控制和生存率.
主要成果:
- 离子RT在老年人和患有HCC的sarcopenic患者中耐受良好.
- 在儿童皮格A/B或ALBI 1/2患者中,单个HCC>30mm显示出出色的结果.
- 5年的局部控制和生存率很高,辐射引起的肝损伤等不良事件很少.
- 晚期HCC与门静脉瘤血栓在特定情况下可能会受益.
结论:
- 碳离子放射治疗 (C-离子RT) 是对HCC的安全有效治疗方法.
- 离子RT为较大的HCC提供了优秀的局部控制和生存率.
- 离子RT代表了对HCC管理的有前途的治疗进展.
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