选择性内镜中GLP-1受体激动剂的周边程序安全性:一个多中心回顾性队列研究
Harsimran Kalsi1,2, Raghav Bassi3, Hussein Noureldine1,2
1Department of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL 32827, USA.
Journal of clinical medicine
|September 13, 2025
概括
类似葡萄糖-1受体激动剂 (GLP-1RA) 在选择性内镜中不会增加周围手术并发症. 这项研究没有发现吸血风险增加,GLP-1RA使用者显示氧气需求较少,住院时间较短.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 临床药理学 临床药理学
背景情况:
- 已知类似葡萄糖-1受体激动剂 (GLP-1 RAs) 可以延迟胃排空.
- 这种影响引发了人们对选择性内镜手术的周围手术安全性的担忧.
研究的目的:
- 评估在进行内镜检查的患者的手术前GLP-1RA使用和手术后并发症之间的关联.
- 特别调查吸入性肺炎和其他不良事件的风险.
主要方法:
- 成年患者进行门诊食道胃二透镜或结肠镜的回顾性队列研究.
- 患者被分为GLP-1RA使用者 (n=953) 或非使用者 (n=3289).
- 结果包括吸气,氧气需求,低血压,住院,ICU入院,住院时间和死亡率,以混因素和麻醉类型进行调整.
主要成果:
- 在这两组中都没有观察到任何愿望事件.
- GLP-1 RA使用与术后氧气需求和死亡率明显降低,住院时间缩短有关.
- 低血压和ICU入院率相似;然而,在监控麻醉护理/中度镇静 (MAC/MS) 下的GLP-1RA使用者与全身麻醉 (GA) 相比,住院几率更高.
结论:
- 在选择性内镜中,手术前GLP-1RA治疗与手术前并发症的增加无关.
- 虽然GLP-1 RA使用者的MAC/MS麻醉显示出更高的住院率,但其他显著的不良结果没有增加.
- 需要进一步的前性研究来阐明这种患者群体中麻醉选择的影响.
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