狼性炎患者底层组织学活性的临床预测因素:聚焦尿液溶解CD163
Bogdan Obrișcă1,2, Alexandra Vrabie1,2, Ștefan Lujinschi1,2
1Nephrology Department, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Journal of clinical medicine
|September 13, 2025
概括
尿溶性蛋白CD163 (usCD163) 显示为狼性炎 (LN) 组织学活性的生物标志物具有前途. 这种可溶性标志物与脏炎症相关,可以帮助区分活跃疾病和慢性变化.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 狼性炎 (LN) 诊断和监测需要脏活检来评估组织学活性.
- 确定可靠的LN活动的非侵入性生物标志物对于患者管理至关重要.
研究的目的:
- 评估尿溶性蛋白CD163 (usCD163) 作为狼性炎患者组织学活性的临床预测因子.
- 为了比较usCD163与蛋白尿和血液尿等传统标记物的疗效,预测脏活检结果.
主要方法:
- 一项回顾性横截面研究,涉及42名性炎患者接受脏活检.
- 测量尿液溶解蛋白CD163 (usCD163) 从活检前收集的第一天早上的空白样本.
- 对usCD163水平和临床/组织学参数之间的相关性分析,包括活动指数 (AI) 和慢性指数 (CI).
主要成果:
- usCD163与24小时蛋白尿,血液和血清补充水平 (C3,C4) 有显著的相关性.
- usCD163与活动指数 (AI) 和活跃的球粒状病变有显著的相关性,但与慢性指数 (CI) 没有相关性.
- usCD163显示,在分辨高AI时,曲线下面的面积 (AUC) 比血质量更高,最佳切线为296.2 ng/mmol.
结论:
- 尿溶性蛋白CD163 (usCD163) 是狼性炎中球炎症的标志物.
- usCD163可以帮助区分组织学活性和慢性,并识别最小活性,尽管它没有显著优于蛋白尿.
更多相关视频
相关概念视频
Nephrotic Syndrome II : Assessment and Medical Management
203
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
203
Nephrotic Syndrome I : Introduction
504
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
504
Chronic Kidney Disease I: Introduction
573
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
573
Urine Studies I: Urinalysis
1.2K
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
1.2K


