在SARS-CoV-2大流行期间急性水出血:国家多中心观察研究
Gabriel Allo1, Stefanie Quickert2, Karsten Große3
1Department for Gastroenterology and Hepatology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, 50937 Cologne, Germany.
Journal of clinical medicine
|September 13, 2025
概括
在德国,COVID-19大流行并没有显著影响急性水出血 (AVB) 患者的治疗结果. 对AVB的管理实践仍然具有弹性,尽管跨内肝移植系统 (TIPS) 的使用增加了.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19大流行给全球医疗保健系统带来了挑战.
- 人们对其对慢性肝病患者的影响感到担忧,特别是肝脏衰竭,如急性水出血 (AVB).
研究的目的:
- 评估COVID-19大流行对德国AVB的肝硬化患者临床结果的影响.
- 为了比较疫情前和疫情期间的患者结果.
主要方法:
- 追溯性国家多中心研究.
- 在四个德国高等医疗中心治疗的肝硬化和AVB患者的比较.
- 数据收集自大流行前 (2016-2020) 和大流行 (2020-2022) 期间的数据.
主要成果:
- 在6周死亡率 (32.2%对30.1%) 或再出血率 (22.8%对22.3%) 中,期间之间没有显著差异.
- 可以比较的感染率,ICU住院和输管.
- 在大流行期间,越来越多地使用跨内肝移植系统分流 (TIPS) 放置 (23.2%对11.3%).
- 在大流行期间,代谢功能障碍相关的脂肪性肝病 (MASLD) 的患病率更高.
结论:
- 与AVB相关的患者结局在很大程度上不受德国三级中心COVID-19大流行的影响.
- 关键的AVB管理实践表明了弹性.
- 增加TIPS的使用率和MASLD的流行率需要进一步调查不断变化的临床实践和患者个人资料.
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