补充5-基托芬对新加坡老年人的认知功能和情绪的影响:一项随机对照试验
Shuqi Li1, Clarinda Nataria Sutanto1, Xuejuan Xia1
1Department of Food & Technology, National University of Singapore, Singapore 117542, Singapore.
Nutrients
|September 13, 2025
概括
这项研究发现,补充5-三 (5-HTP) 改善了新加坡老年人的认知功能,减少了新加坡老年人的抑郁症状. 由于样本规模小,研究时间短,需要进一步研究.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 营养科学 营养科学
背景情况:
- 认知能力下降是一个日益严重的公共卫生问题,特别是全球人口老龄化.
- 饮食补充剂,如5-基三丰 (5-HTP),是血清素的前体,正在探索神经保护作用.
- 关于5-HTP对认知功能的影响的证据有限,特别是在亚洲老年人中.
研究的目的:
- 为了研究5-HTP补充剂对新加坡老年人的认知功能和情绪的影响.
- 探索5-HTP在缓解与年龄相关的认知衰退和情绪障碍方面的潜力.
主要方法:
- 一项为期12周的单盲随机受控试验,涉及30名66岁±3岁的参与者.
- 参与者被随机分配,每天接受100毫克5-HTP或安慰剂.
- 评估了认知功能 (MoCA) 和情绪 (GAI,GDS),以及血液生物标志物 (血清素,Aβ40,Aβ42,GABA).
主要成果:
- 在5-HTP组中观察到蒙特利尔认知评估 (MoCA) 评分的显著改善.
- 5HTP组显示了血清血红水平的显著增加.
- 在5-HTP组中,老年抑郁量表 (GDS) 的得分显著下降;对GAI没有影响.
结论:
- 5HTP补充剂可以提高认知表现,并减轻新加坡老年人的抑郁症状.
- 潜在的机制涉及到调节血清能系统.
- 由于样本规模小,干预时间短,结果是初步的;需要进行更大规模的长期研究.
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