素补充剂改善了中年和老年2型糖尿病患者的微血管功能和肌肉力量
Arturo Figueroa1, Katherine N Dillon1,2, Danielle E Levitt1
1Department of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX 79409, USA.
Nutrients
|September 13, 2025
概括
在2型糖尿病患者中,素补充改善了微血管内皮功能和肌肉强度. 这表明,在治疗血管并发症和与年龄有关的肌肉损失方面,有潜在的治疗益处.
科学领域:
- 心血管研究研究心血管研究
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 2型糖尿病 (T2D) 与由阿金缺乏和内皮功能障碍驱动的血管并发症有关.
- 这些血管问题加剧了与年龄相关的肌肉力量 (MS) 的下降.
- 氧化 (NO) 介导的血管扩张可能会增强MS,提供潜在的治疗点.
研究的目的:
- 研究素补充剂对T2D患者微血管功能和MS的影响.
- 评估素对内皮功能,肌肉微血管反应能力和血中阿尔金宁水平的影响.
- 为了确定素补充剂是否可以改善手握和小腿肌肉力量.
主要方法:
- 一个随机交叉试验,涉及16名T2D参与者 (53-72岁).
- 参与者接受了素补充剂 (6克/天) 或安慰剂4周,随后是洗期,然后是替代治疗.
- 测量包括内皮功能 (LnRHI),肌肉反应率 (TOI),血中阿尔金因 (ARG) 和肌肉强度 (HGSrel,CMSrel).
主要成果:
- 与安慰剂相比,花素补充剂显著增加了LnRHI,TOI再注射指数和ARG水平.
- 通过使用素观察到小牛肌肉强度 (CMS和CMSrel) 的显著改善.
- 在内皮功能 (LnRHI) 和小腿肌肉力量 (CMSrel) 的改善之间发现了积极的相关性.
结论:
- 素补充剂有效地提高T2D患者的微血管内皮功能.
- 这项研究表明,素能够改善肌肉微血管反应能力和小腿肌肉强度.
- 这些发现表明,素是T2D患者血管和肌肉健康的有希望的干预措施.
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