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在绝经前妇女的系统性炎症指数,化学因子和代谢标志物

Anna Maria Cybulska¹, Kamila Rachubińska¹, Elżbieta Grochans¹

¹Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska 48 St., 71-210 Szczecin, Poland.

|September 13, 2025

概括

系统性免疫-炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 与超重的绝经前妇女的化学因子相关. 这些指数可能有助于选代谢综合征 (MetS) 风险.

科学领域:

内分泌学和新陈代谢学
免疫学免疫学免疫学
妇女健康妇女健康

背景情况:

更年期和代谢综合征 (MetS) 与慢性低级炎症有关.
在绝经前妇女中,特定的炎症标志物,如化学因子,SII和SIRI的作用尚不清楚.

研究的目的:

在绝经前妇女中调查炎症标志物,化学因子和全身指数.
探索身体质量指数 (BMI),炎症和代谢综合征指标之间的关系.

主要方法:

对230名波兰绝经前妇女 (44-65岁) 的横截面研究.
收集的社会人口统计,健康,人类测量和实验室数据.
分析了炎症标志物 (IL-6,CRP),胰岛素耐药性 (HOMA-IR),化学因子 (CXCL2,CXCL5,CXCL9) 和全身指数 (SII,SIRI).

主要成果:

超重妇女 (BMI ≥25 kg/m2) 显示较高的IL-6,CRP和HOMA-IR.
SII与CXCL5正相关;SIRI与CXCL2,CXCL5和CXCL9相关.
在化学因子和SII/SIRI之间观察到BMI依赖的相关性.

结论:

绝经前妇女的体重过重与炎症和胰岛素抵抗增加有关.
在这个人群中,SII和SIRI显示出作为MetS风险可访问的查工具的潜力.
需要进一步的纵向研究来验证SII和SIRI的预测价值和临床实用性.

关键词:

在这里,SILLO.斯里里斯拉夫斯里里斯拉夫化学物质 (chemokines) 是一种化学物质.代谢综合征代谢综合征周周更年期周周更年期系统性炎症系统性炎症

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