两种复合益生菌配方对胃肠道症状和肠道微生物群的影响:为期4周的随机双盲干预试验
Zhen Qu1, Ying Wu1,2, Yiru Jiang1
1College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China.
Nutrients
|September 13, 2025
概括
高剂量的益生菌有效地管理胃肠道 (GI) 症状并改善肠道健康. 与Wec120B相比,Wec300B配方显示出优越的微生物调节,这表明剂量影响结果.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 营养科学 营养科学
背景情况:
- 只有有限的证据可以比较多菌株益生菌在不同剂量的疗效.
- 益生菌干预显示出减轻胃肠道 (GI) 不适的潜力.
- 了解配方功效对于优化益生菌使用至关重要.
研究的目的:
- 为了比较两种高剂量多菌株益生菌配方 (Wec120B和Wec300B) 的临床和微生物组结局.
- 评估益生菌配方功效对症状缓解和肠道微生物群调节的影响.
- 评估对特定的胃肠道症状,肠道微生物组成和关键生物标志物的影响.
主要方法:
- 一项为期4周的随机双盲试验,涉及100名成年人.
- 参与者接受了两种多菌株益生菌配方之一 (Wec120B或Wec300B).
- 通过每周的胃肠道症状评分表 (GSRS) 评分来跟踪症状;通过16S rRNA测序来分析肠道微生物群;评估生物标志物 (LPS,FC,IGA).
主要成果:
- Wec120B 早期改善了腹部疼痛; Wec300B 对反流症状更有效.
- Wec120B降低了脂聚糖 (LPS); Wec300B增加了免疫球蛋白A (IgA) 和降低了便蛋白 (FC).
- 这两种配方都增加了有益细菌 (例如,Bifidobacterium) 和减少了病原体 (例如,Prevotella).
结论:
- 这两种益生菌配方都显著改善胃肠道症状,并调节肠道微生物群.
- Wec300B表现出优越的微生物调节,可能是由于其较高的益生菌剂量.
- 研究结果支持益生菌在肠道健康管理中的合理应用.
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