塑原结合M蛋白D域中的疏水性残留物调节了Streptococcus pyogenes中的α-helicity,寡合化和表面定

Olawole Ayinuola1, Yetunde A Ayinuola1, Zhong Liang1

  • 1W.M. Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.

概括

M-蛋白D域对A组链球菌的毒性至关重要,影响蛋白质结构,细菌细胞表面的附着和人类等离子体激活. 突变破坏了这些功能,影响了GAS的发病.

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