相关实验视频

Updated: Jan 18, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

综合生物信息学和实验研究将环林B1/B2与子宫内膜癌的不良预后和免疫透联系起来

Haikun Yang¹, Zhengping Zhang¹, Haochang Liu¹

¹Meizhou People's Hospital, Meizhou, Guangdong, China.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

|September 13, 2025

概括

循环B1 (CCNB1) 和循环B2 (CCNB2) 的高表达与子宫内膜癌 (EC) 的预后不佳相关. 这些基因可以作为高级或复发性EC的新疗法标和预后标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

对于晚期或复发的病例,子宫内膜癌 (EC) 的预后不佳,需要新的治疗点.
循环B1 (CCNB1) 和循环B2 (CCNB2) 表达在EC严重性中的作用需要研究.

研究的目的:

分析CCNB1和CCNB2表达和EC疾病严重程度之间的相关性.
确定子宫内膜癌的潜在预后标志物和治疗点.

主要方法:

在EC队列中的差异基因表达分析.
构建一个蛋白质-蛋白质相互作用 (PPI) 网络以识别枢纽基因.
在外部数据集中验证基因表达和使用TCGA数据进行预后评估.

主要成果:

确定了CCNB1和CCNB2作为顶级枢纽基因.
在欧洲共同体,高CCNB1/CCNB2表达与更短的生存期和更严重的疾病严重程度有关.
与免疫细胞透和免疫检查点基因表达相关的CCNB1/CCNB2过度表达.

结论:

CCNB1和CCNB2显示出作为子宫内膜癌的预后标志物的潜力.
CCNB1和CCNB2可能代表了EC管理的新疗法目标.

关键词:

这是子宫内膜癌的癌症.环 B1 环 B1 是一种环.环 B2 环 B2 环 B2 是一种免疫检查点蛋白质的免疫检查点蛋白质不匹配的维修维修不匹配的维修

更多相关视频

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

相关概念视频

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

Positive Regulator Molecules

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

M-Cdk Drives Transition Into Mitosis

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...