基于氧化石烯的光热和光动力疗法-一个系统性审查
Shahrukh Khan1, Humaira Batool1, Huraira Tariq1
1Department of Biomedical Engineering and Sciences, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology, Islamabad, Pakistan.
Journal of biomedical materials research. Part B, Applied biomaterials
|September 13, 2025
概括
石墨烯氧化物纳米材料在光热疗法和光动力疗法方面表现有前途. 本综述分析了它们的设计,有效性和临床翻译在生物医学应用中的局限性.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 光热疗法 (PTT) 和光动力疗法 (PDT) 是先进的医学治疗方法.
- 石墨烯氧化物 (GO) 和减少的石墨烯氧化物 (rGO) 是PTT的理想纳米材料,因为它们的近红外光响应和热转换.
- 广泛的研究集中在基于GO的光热剂,用于PTT和PDT.
研究的目的:
- 在过去的十年里,系统地审查对光疗的石墨烯基光热纳米系统的研究.
- 概述这些平台在生物医学应用中的设计,有效性和局限性.
- 确定研究缺口,并指导理想的光疗多功能纳米系统的开发.
主要方法:
- 对过去10年发表的研究进行系统的文献综述.
- 在PubMed上使用特定关键字和布尔运算符的搜索策略.
- 分析仅限于全文文章.
主要成果:
- 基于石墨烯的光热平台已经在各种体外和体内生物医学应用中进行了测试,主要用于抗菌和抗癌模型.
- 这些平台在提高治疗结果方面表现出有效性.
- 局限性阻碍了目前基于GO的光热剂的标准化和临床转化.
结论:
- 基于石墨烯的光热纳米系统为光疗提供了重要的潜力.
- 需要进一步的研究来克服临床翻译的现有局限性.
- 开发理想的多功能纳米系统需要解决当前的设计缺陷.
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